Search results for "behavioral reactivity"
showing 2 items of 2 documents
Long-lasting handling affects behavioural reactivity in adult rats of both sexes prenatally exposed to diazepam
2001
Environmental stressors can substantially affect the adaptive response of rats to novelty in a sexually dimorphic manner. Gender-related differences are also observed in neurochemical and behavioural patterns of adult rats following prenatal exposure to diazepam (DZ). In the present study the behavioural reactivity to novelty is investigated in open field (OF) and in acoustic startle reflex (ASR) tests, in non handled (NH), short-lasting handled (SLH) and long-lasting handled (LLH) adult male and female rats prenatally exposed to DZ. A single daily s.c. injection of DZ (1.5 mg/kg) over gestation days 14-20 decreases GABA/BDZ receptor function in both sexes, as shown by the decreased electro…
ETHANOL DRINKING PATTERN DIFFERENTLY AFFECTS NOVELTY-RELATED BEHAVIOUR DURING ABSTINENCE IN FEMALE RATS
2014
Withdrawal from chronic ethanol leads to a multifaceted syndrome, characterized by negative affective state. Novelty seeking and motivation, closely related to affective state, can be assessed in rodents exploring behavioural response to novelty. This study aims at assessing novelty-related behaviour in female rats during ethanol withdrawal following different self-administration patterns. Female rats underwent 9-week-, 2-bottle choice-, continuous or intermittent (3 days/week) access to 20% ethanol; they were named CARs and IARs respectively. After 12h from last ethanol access, they were tested for locomotor activity induced by a novel environment; time spent in the central area of an open…